HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-Fluoro-alpha-(2-methyl-5-methoxyphenoxy)acetophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Methoxy-2-methylphenol | HCID 10953582 | — |
| Reactant | 2-Bromo-2-fluoro-1-phenylethan-1-one | HCID 12545127 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 2-Fluoro-alpha-(2-methyl-5-methoxyphenoxy)acetophenone | HCID 21319887 | — |
Reaction Steps
Using the method described in Example 17, equimolar amounts of 2-hydroxy-4-methoxytoluene and α-bromo-2-fluoroacetophenone are refluxed in benzene in the presence of potassium carbonate to provide 2-fluoro-α-(2-methyl-5-methoxyphenoxy)acetophenone. Recrystallization from cyclohexane provides a tan solid, m.p. 57°-58° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04153619 |
| Source dataset | uspto-grants-1979_05 |
| ORD ID | ord-3e851856db374d72af6a9b2abc83912c |
| Source note | uspto-grants-1979_05 |