Sodium Cyanide → HCID 21319927, compound

HRID 262095Notes

Reaction equation

[Br:1][C:2]1[O:3][C:4]2[C:17]([CH2:18]Br)=[CH:16][CH:15]=[C:14]([O:20][CH3:21])[C:5]=2[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[F:13].[C-:22]#[N:23].[Na+]>>[Br:1][C:2]1[O:3][C:4]2[C:17]([CH2:18][C:22]#[N:23])=[CH:16][CH:15]=[C:14]([O:20][CH3:21])[C:5]=2[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[F:13]

Participants

Reactant 2

HCID 8929Sodium Cyanide

HCID 21319942HCID 21319942, compound

Product 1

HCID 21319927HCID 21319927, compound

Procedure

Using the method of Example 17, 2-bromo-7-bromomethyl-3-(2-fluorophenyl)-4-methoxybenzofuran is reacted with sodium cyanide to provide 2-bromo-7-cyanomethyl-3-(2-fluorophenyl)-4-methoxybenzofuran as a brown solid after isolation by column chromatography.

Sources & evidence

ORD record: ord-4f8dbfddf6f34305bf4f980051a2611c
Source dataset: uspto-grants-1979_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04153619

Reaction notes

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