Nitrogen oxide (N2O4) → HCID 85893998, compound

HRID 262096Notes

Reaction equation

HRID 262096 reaction equation
Br[C:2]1([CH2:20][C:21]([OH:23])=[O:22])[CH:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])[C:9]([O:18][CH3:19])=[C:5]2[CH:6]=[CH:7][CH:8]=[C:4]2[O:3]1.[N+:24]([O-:29])([N+]([O-])=O)=[O:25]>>[F:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[CH:10]1[C:9]([O:18][CH3:19])=[C:5]2[CH:6]=[CH:7][CH:8]=[C:4]2[O:3][C:2]1([N+:24]([O-:29])=[O:25])[CH2:20][C:21]([OH:23])=[O:22]

Participants

3

Reactant 2

HCID 25352Nitrogen oxide (N2O4)HCID 70609358HCID 70609358, compound

Product 1

HCID 85893998HCID 85893998, compound

Procedure

Using the method of Example 17, 2-bromo-3-(2-fluorophenyl)-4-methoxy-7-benzofuranacetic acid is reacted with dinitrogen tetroxide to provide 3-(2-fluorophenyl)-4-methoxy-2-nitro-7-benzofuranacetic acid. Recrystallization of the acid from benzene provides yellow crystals, m.p. 185°-195° C.

Sources & evidence

ORD record
ord-b57ac84e15d74f4f826b25a175f09c0b
Source dataset
uspto-grants-1979_05
Patent number
US04153619

Reaction notes

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