反应详情

(S)-1,5,10,10a-Tetrahydrothiazolo[3,4-b]isoquinoline-3-thione (38 g) is dissolved in methyl iodide (500 cc). After 15 hours at a temperature of about 20° C., the resulting crystals are filtered off, washed with diethyl ether (2×50 cc) and then dried at 20° C. under reduced pressure (1 mm Hg). (S)-3-Methylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide (61.5 g), which melts at 140°-150° C. with decomposition, is thus obtained.

1. filtrationthe resulting crystals are filtered off
2. washwashed with diethyl ether (2×50 cc)
3. customdried at 20° C. under reduced pressure (1 mm Hg)