(S)-3-Methylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide → (S)-3-[(3-propylisoquinol-5-yl)imino]-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinoline

Participants

Reaction Steps

By following the procedure of Example 3 but using 5-amino-3-propylisoquinoline (0.18 g) and (S)-3-methylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide (0.35 g) as starting materials, (S)-3-[(3-propylisoquinol-5-yl)imino]-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinoline (0.35 g) is obtained in a crude form, which is purified by chromatography on a column (diameter of the column: 0.7 cm) containing silica (6 g) by eluting with methylene chloride and collecting the eluate in 20 cc fractions.

Provenance & Evidence