Phosphorus sulfide (P2S5) → Thiazole, 2,5-diphenyl-

HRID 262126Notes

Reaction equation

HRID 262126 reaction equation
[C:1]([NH:9][CH2:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=O)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:20]>>[C:2]1([C:1]2[S:20][C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:10][N:9]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 14817Phosphorus sulfide (P2S5)HCID 259631BENZAMIDO ACETOPHENONE

Product 1

HCID 3014233Thiazole, 2,5-diphenyl-

Procedure

Another sample of 2,5-diphenylthiazole is prepared by reacting alpha-(benzamido) acetophenone with phosphorus pentasulfide according to the procedure given by Gabriel, Berichte 43, 137 (1910); C.A. 4, 928. The overall yield, based on phenacyl bromide, is about 25% and the product melts at 103°-106° C.

Sources & evidence

ORD record
ord-b97d0588c6d640239faed29416900dda
Source dataset
uspto-grants-1979_05
Patent number
US04153703

Reaction notes

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