Carbon Tetrachloride → HCID 20570489, compound

HRID 262135Notes

Reaction equation

HRID 262135 reaction equation
C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([F:30])([F:29])[F:28])[CH:22]=3)=[CH:14][C:15]([CH3:20])([CH3:19])[O:16]2)=[CH:11][CH:10]=1)C1C=CC=CC=1.C(Cl)(Cl)(Cl)Cl>C(O)C.[Pd]>[CH3:19][C:15]1([CH3:20])[CH2:14][CH:13]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([F:29])([F:28])[F:30])[CH:22]=2)[C:12]2[C:17](=[CH:18][C:9]([OH:8])=[CH:10][CH:11]=2)[O:16]1

Participants

5

Reactant 2

HCID 5943Carbon Tetrachloride2×HCID 12071756HCID 12071756, compound

Product 1

HCID 20570489HCID 20570489, compoundYield 98%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

7-Benzyloxy-2,2-dimethyl-4-(3-trifluoromethylphenyl)-2H-chromene (10.0 g) was dissolved in ethanol (100 ml) and 10% Pd/C (1 g) added. This was hydrogenated at 60° and 5 atmospheres pressure for 18 hours. Filtration through kiesleguhr and evaporation of the solvent under reduced pressure gave an oil which solidified on addition of carbon tetrachloride. Recrystallisation from carbon tetrachloride gave the title compound (7.7 g), m.p. 63°-68° C., (analysing as compound plus 1 mole of carbon tetrachloride).

Workup

  1. customThis was hydrogenated at 60°
  2. filtrationFiltration
  3. customthrough kiesleguhr and evaporation of the solvent under reduced pressure
  4. customgave an oil which
  5. customRecrystallisation from carbon tetrachloride

Sources & evidence

ORD record
ord-63cadf7d89e546ca9319ccf7c145ff6e
Source dataset
uspto-grants-1979_05
Patent number
US04153617

Reaction notes

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