Hydrochloric Acid → HCID 54420298, compound

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 40 g. of cuprous cyanide and 99 g. (0.29 mole) of methyl 3-(4-bromophenyl)benzofuran-5-acetate in 30 ml. of pyridine is heated at 160°-175° C. under a nitrogen atmosphere for 20 hours, cooled to about 100° C., and then a solution of 200 g. of ferric chloride, 100 ml. of concentrated hydrochloric acid and 200 ml. of ice water is added. To this mixture is added 300 ml. of chloroform, and stirring is continued for one hour. The solid is separated by filtration and washed with chloroform. The filtrate and washings are combined, dried, then evaporated to provide a residue which is recrystallized from an N,N-dimethylformamide-water mixture to provide methyl 3-(4-cyanophenyl)-benzofuran-5-acetate.

Provenance & Evidence