Ethanol → HCID 20333807, compound

Participants

Reaction Steps

To a suspension of 5 g. of the product of step A in 20 ml. of ethanol is added 50 ml. of 30 percent sodium hydroxide solution, and the mixture is refluxed for 30 minutes, 75 ml. of water is added, and the mixture is refluxed for an additional three hours. The mixture is decanted into 125 ml. of 6N hydrochloric acid, the solid is separated by filtration then recrystallized from acetic acid to provide 3-(4-carboxyphenyl)benzofuran-5-acetic acid, m.p. 278°-281° C.

Provenance & Evidence