Hydrochloric Acid → HCID 21320323, compound

Participants

Reaction Steps

To a stirred mixture of 0.11 g. of sodium borohydride in 5 ml. of glyme is added dropwise 1.7 g. (0.0064 mole) of 2-nitro-3-phenyl-7-benzofuranaldehyde in 45 ml. of glyme. After 30 minutes, a small portion of 10 percent sodium hydroxide solution is added, then 20 ml. of water, then enough 6N hydrochloric acid to acidify the mixture. The mixture is then extracted with dichloromethane, the extracts are washed twice with water and dried. Evaporation provides a residue which solidifies. Recrystallization twice from a benzene-hexane mixture provides yellow 7-hydroxymethyl-2-nitro-3-phenylbenzofuran, m.p. 128.5°-130° C.

Provenance & Evidence