Bromine → HCID 21320312, compound

HRID 262220Notes

Reaction equation

HRID 262220 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]2[O:11][CH:10]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:8]=2[CH:18]=1.[Br:19]Br>ClCCl>[Br:19][C:10]1[O:11][C:7]2[CH:6]=[CH:5][C:4]([CH2:3][CH2:2][OH:1])=[CH:18][C:8]=2[C:9]=1[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 21320291HCID 21320291, compound

Product 1

HCID 21320312HCID 21320312, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
15 °C

Procedure

The product from step A is dissolved in 200 ml. of dichloromethane, the solution is cooled to 5° C., and 9.16 g. (0.0573 mole) of bromine in 50 ml. of dichloromethane is added dropwise. The solution is allowed to warm to 15° C., then evaporated to provide a green residue of 2-bromo-5-(2-hydroxyethyl)-3-phenylbenzofuran. The structural assignment is confirmed by infrared and nuclear magnetic resonance spectral analysis.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-5262c300e00145298e24443e890eff00
Source dataset
uspto-grants-1979_05
Patent number
US04153716

Reaction notes

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