3-Cyclohexene-1-carboxylic acid → HCID 21320309, compound

Participants

Reaction Steps

The product from step B is mixed with 8.83 g. (0.07 mole) of cyclohexene-4-carboxylic acid in 175 ml. of chloroform, and 6.5 g. (0.07 mole) of dinitrogen tetraoxide in 15 ml. of chloroform is added dropwise. After 30 minutes an additional 1.0 g. of dinitrogen tetraoxide in 5 ml. of chloroform is added, and the mixture is stirred for about 18 hours. The mixture is washed twice with water, twice with saturated sodium bicarbonate solution and twice again with water, then dried. Evaporation to dryness provides a residue which is recrystallized from aqueous ethanol, then benzene, to provide 5-(2-hydroxyethyl)-2-nitro-3-phenylbenzofuran as a yellow solid, m.p. 169°-173° C.

Provenance & Evidence