L-Proline → HCID 53753559, compound

Participants

Reaction Steps

A mixture of 1.04 g. (0.009 mole) of proline and 3 g. (0.009 mole) of 5-(2-bromoethyl)-2-nitro-3-phenylbenzofuran (prepared by reaction of 5-(2-hydroxyethyl)-2-nitro-3-phenylbenzofuran with phosphorus tribromide) in 50 ml. of ethanol is heated to its reflux temperature and maintained at reflux temperature for about 14 hours. The mixture is evaporated to provide a solid residue which is recrystallized from ethanol to provide 5-ethoxyethyl-2-nitro-3-phenylbenzofuran, m.p. 108°-109° C.

Provenance & Evidence