HCID 11736265, compound → HCID 57194601, compound

HRID 262241Notes

Reaction equation

HRID 262241 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].[CH2:7]([S:14][CH2:15][CH2:16][C@@H:17]([C:19](O)=[O:20])[NH2:18])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>CCOCC>[CH2:7]([S:14][CH2:15][CH2:16][C@@H:17]([CH2:19][OH:20])[NH2:18])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 11736265HCID 11736265, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 57194601HCID 57194601, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a suspension of 43 g of LiAlH4 (4 times the theoretical amount) in 1000 ml of anhydrous ether brought to reflux under mechanical agitation, there is added a solution of 144 g of the ethyl ester of the S-benzylhomocysteine in 600 ml of anhydrous ether at a speed such that the reaction mixture continues to boil. After the end of the addition, refluxing is continued for 1 hour.

Workup

  1. temperatureto reflux under mechanical agitation, there
  2. additionAfter the end of the addition
  3. temperaturerefluxing

Sources & evidence

ORD record
ord-075daf00f98c48d293acae483b62a7b9
Source dataset
uspto-grants-1979_05
Patent number
US04153729

Reaction notes

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