HCID 54348907, compound → 5xi-hydroxy-7-amino-6,7,8,9-tetrahydro [5 H] benzocycloheptene
Reaction equation
[OH:1][CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][CH2:5][CH:4]([NH:13]CC2C=CC=CC=2)[CH2:3]1>C(O)C>[OH:1][CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][CH2:5][CH:4]([NH2:13])[CH2:3]1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
8 g of 10% palladized carbon were added to a mixture of 8.2 g of the product of Step B in 250 ml of absolute ethanol and the mixture was heated to 80° C. under a hydrogen atmosphere for 30 minutes. The mixture was filtered and the filter was washed with ethanol. The filtrate was evaporated to dryness under reduced pressure to obtain 5.6 g of a mixture of the two isomers of 5ξ-hydroxy-7-amino-6,7,8,9-tetrahydro [5H] benzocycloheptene in the form of resin which was used as is for the next step.
Workup
- filtrationThe mixture was filtered
- washthe filter was washed with ethanol
- customThe filtrate was evaporated to dryness under reduced pressure
Sources & evidence
- ORD record
- ord-775987163ad04fca93ce64e129f6d641
- Source dataset
- uspto-grants-1979_04
- Patent number
- US04148919
Reaction notes
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