反应详情

温度

80 °C

8 g of 10% palladized carbon were added to a mixture of 8.2 g of the product of Step B in 250 ml of absolute ethanol and the mixture was heated to 80° C. under a hydrogen atmosphere for 30 minutes. The mixture was filtered and the filter was washed with ethanol. The filtrate was evaporated to dryness under reduced pressure to obtain 5.6 g of a mixture of the two isomers of 5ξ-hydroxy-7-amino-6,7,8,9-tetrahydro [5H] benzocycloheptene in the form of resin which was used as is for the next step.

1. filtrationThe mixture was filtered
2. washthe filter was washed with ethanol
3. customThe filtrate was evaporated to dryness under reduced pressure