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HRID262298

反应详情

EQUATION

反应方程式

HRID 262298 的结构方程式

REACTANTS

反应物

2
结构：[N-]=[N+]=[N-].[Na+]
HCID33557

未命名化合物

结构：O=C(CCl)N1CC(c2ccccc2)c2ccccc21
HCID21320458

2-Chloro-1-(3-phenyl-2,3-dihydro-1H-indol-1-yl)ethan-1-one

C16H14ClNO

PRODUCTS

生成物

1
结构：[N-]=[N+]=NCC(=O)N1CC(c2ccccc2)c2ccccc21
HCID21320467

2-Azido-1-(3-phenyl-2,3-dihydro-1H-indol-1-yl)ethan-1-one

C16H14N4O

收率 68.3%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CCO
溶剂HCID702

Ethanol

C2H6O

结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A solution of 4.0 g of N-chloroacetyl-3-phenylindoline and 1.1 g of sodium azide in 70 ml of 80% aqueous ethanol was refluxed for one hour. After cooling, the solution was diluted with 100 ml of water and extracted with methylene chloride. Evaporation of the solvent gave 2.8 g of the desired N-azidoacetyl-3-phenylindoline having a melting point of 72°-3° C.

WORKUP

后处理

  1. temperatureAfter cooling
  2. extractionextracted with methylene chloride
  3. customEvaporation of the solvent