2-(2-Chlorophenyl)-4-(diisopropylamino)butanenitrile → alpha-(o-Chlorophenyl)-alpha-[2-(diisopropylamino)ethyl]-alpha-(2-piperidinoethyl)acetonitrile

Participants

Reaction Steps

When an equivalent quantity of α-(o-chlorophenyl)-α-[2-(diisopropylamino)ethyl]acetonitrile prepared according to the first paragraph of Example 19, is substituted for α-(o-fluorophenyl)-α-[2-(diisopropylamino)ethyl]acetonitrile called for in Example 20 and the procedure detailed in the second paragraph of that example is substantially repeated, there is obtained α-(o-chlorophenyl)-α-[2-(diisopropylamino)ethyl]-α-(2-piperidinoethyl)acetonitrile, as an oil boiling at about 190°-195° C. at 0.3 mm. pressure.

Provenance & Evidence