HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Diisopropylamino)ethyl chloride → alpha-[2-(Diisopropylamino)ethyl]-alpha-(2-piperidinoethyl)-alpha-(2-pyridyl)acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Diisopropylamino)ethyl chloride | HCID 7312 | — |
| Reactant | 1-(2-Chloroethyl)piperidine | HCID 74827 | — |
| Reactant | 4-Diisopropylamino-2-phenyl-butyronitrile | HCID 12612210 | — |
| Reactant | 4-Diisopropylamino 2-(2-pyridyl)butyronitrile | HCID 13319674 | — |
| Product | alpha-[2-(Diisopropylamino)ethyl]-alpha-(2-piperidinoethyl)-alpha-(2-pyridyl)acetonitrile | HCID 21320527 | — |
Reaction Steps
Substitution of equivalent quantities of α-[2-(diisopropylamino)ethyl]-α-(2-pyridyl)acetonitrile and 1-(2-chloroethyl)piperidine for α-[2-(diisopropylamino)ethyl]-α-phenylacetonitrile and 2-chloro-N,N-diisopropylethylamine called for respectively in the procedure of Example 2, Method B affords α-[2-(diisopropylamino)ethyl]-α-(2-piperidinoethyl)-α-(2-pyridyl)acetonitrile, as an oil boiling at about 160°-170° C. at 0.5-0.7 mm. pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04153797 |
| Source dataset | uspto-grants-1979_05 |
| ORD ID | ord-032e891ed1cb4200a7a8e53af8d9f620 |
| Source note | uspto-grants-1979_05 |