Dimethylamine → 8-chloro-N,N-dimethyl-6-phenyl-4H-pyrazolo[1,5-a][1,4]benzodiazepine-2-carboxamide

Participants

Reaction Steps

This compound was prepared from 700 mg. (1.99 mmol) of the end product of Example 9 and dimethylamine according to a procedure similar to that described above in Example 11. The reaction mixture was heated to 60°-65° in a sealed glass bomb for 16 hours. Recrystallization from acetone/ether/hexane yielded the desired end product: mp 176°-178°.

Provenance & Evidence