HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trityl chloride → Dimethyl 1-trityl-3,5-pyrazoledicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trityl chloride | HCID 6456 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3,5-dimethyl 1H-pyrazole-3,5-dicarboxylate | HCID 1484491 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | N,N-Dimethylformamide--water (1/1) | HCID 21962138 | — |
| Product | Dimethyl 1-trityl-3,5-pyrazoledicarboxylate | HCID 12377531 | — |
Reaction Steps
To a solution of 1.84 g. (10 mmol) of 3,5-pyrazoledicarboxylic acid dimethyl ester* in 15 ml. of DMF, stirred at 0° under argon, was added 480 mg. (10 mmol) of 50% NaH (suspension in mineral oil). After the evolution of hydrogen had ceased, 2.7 g. (10 mmol) of triphenylmethyl chloride in 20 ml. of DMF was added dropwise. The mixture was allowed to warm to room temperature, stirred 1.5 hours, poured into H2O, and the resulting precipitate filtered. After recrystallization from 2-ethoxyethanol-H2O, there was obtained the end product. The analytical sample was obtained as colorless needles by recrystallization from DMF-H2O; mp 212°-213.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04153799 |
| Source dataset | uspto-grants-1979_05 |
| ORD ID | ord-031af27ee6244fe5b4bbed57f3a65bb4 |
| Source note | uspto-grants-1979_05 |