Nalpha-(3-(acetylthio)-2-methoxycarbonylmethylpropanoyl]-L-lysine → Nalpha-[3-mercapto-2-(methoxycarbonylmethyl)propanoyl]-L-lysine

HRID 262379Notes

Reaction equation

HRID 262379 reaction equation
C([S:4][CH2:5][CH:6]([CH2:19][C:20]([O:22][CH3:23])=[O:21])[C:7]([NH:9][C@H:10]([C:16]([OH:18])=[O:17])[CH2:11][CH2:12][CH2:13][CH2:14][NH2:15])=[O:8])(=O)C.C(SCC(CC(OC)=O)C(N[C@H](C(O)=O)CCCNC(=N)N)=O)(=O)C>>[SH:4][CH2:5][CH:6]([CH2:19][C:20]([O:22][CH3:23])=[O:21])[C:7]([NH:9][C@H:10]([C:16]([OH:18])=[O:17])[CH2:11][CH2:12][CH2:13][CH2:14][NH2:15])=[O:8]

Participants

3

Reactant 2

HCID 22803504Nalpha-(3-(acetylthio)-2-methoxycarbonylmethylpropanoyl]-L-lysineHCID 178500599HCID 178500599, compound

Product 1

HCID 22803509Nalpha-[3-mercapto-2-(methoxycarbonylmethyl)propanoyl]-L-lysine

Procedure

By substituting Nα -[3-(acetylthio)-2-(methoxycarbonylmethyl)propanoyl]-L-lysine for the Nα -[3-(acetylthio)-2-(methoxycarbonylmethyl)propanoyl]-L-arginine in the procedure of Example 18, Nα -[3-mercapto-2-(methoxycarbonylmethyl)propanoyl]-L-lysine is obtained.

Sources & evidence

ORD record
ord-2cd4d9b3e174479f9194eee394b92902
Source dataset
uspto-grants-1979_05
Patent number
US04154736

Reaction notes

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