Anthranilic Acid → alpha-[(2-Carboxy-4,5-dimethoxyphenyl)-amino]-gamma-butyrolactone

HRID 262384Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:14])[C:6](=[CH:10][C:11]=1[O:12][CH3:13])[C:7]([OH:9])=[O:8].[C:15]([OH:24])(=[O:23])[C:16]1C(=CC=[CH:21][CH:22]=1)N>>[C:7]([C:6]1[CH:10]=[C:11]([O:12][CH3:13])[C:3]([O:2][CH3:1])=[CH:4][C:5]=1[NH:14][CH:16]1[CH2:22][CH2:21][O:24][C:15]1=[O:23])([OH:9])=[O:8]

Participants

Reactant 2

HCID 227Anthranilic Acid

HCID 797364,5-Dimethoxyanthranilic acid

Product 1

HCID 12701624alpha-[(2-Carboxy-4,5-dimethoxyphenyl)-amino]-gamma-butyrolactone

Procedure

In the method of the Reference Example 1, 4,5-dimethoxyanthranilic acid was reacted in the place of anthranilic acid to obtain α-[(2-carboxy-4,5-dimethoxyphenyl)-amino]-γ-butyrolactone, melting point: 214° C.(decomp.).

Sources & evidence

ORD record: ord-d7fbe09673a94b19903ad24690d12522
Source dataset: uspto-grants-1979_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04154731

Reaction notes

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