Phosgene → HCID 21318672, compound

HRID 262407Notes

Reaction equation

HRID 262407 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[CH2:6][CH2:7][CH2:8][CH:9]([NH2:10])[C:2]1=2.[C:11](Cl)(Cl)=[O:12]>C1(C)C=CC=CC=1>[S:1]1[CH:5]=[CH:4][C:3]2[CH2:6][CH2:7][CH2:8][CH:9]([N:10]=[C:11]=[O:12])[C:2]1=2

Participants

4

Reactant 2

HCID 6371PhosgeneHCID 10773169HCID 10773169, compound

Product 1

HCID 21318672HCID 21318672, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A six gram sample of 4,5,6,7-tetrahydrobenzo[b]thiophen-7-amine is stirred in 20 ml. of toluene at 100° C. and phosgene is slowly introduced into the mixture through a gas tube. The flow of phosgene is terminated after most of the solid amine hydrochloride disappears. The mixture is then filtered and the filtrate is evaporated to dryness to afford the title compound.

Workup

  1. customThe flow of phosgene is terminated after most of the solid amine hydrochloride
  2. filtrationThe mixture is then filtered
  3. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-940f1cdfb7304e3d9bd69f3b60e430f1
Source dataset
uspto-grants-1979_05
Patent number
US04154740

Reaction notes

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