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温度

0 °C

Into a 1 liter reaction flask equipped with mechanical stirrer, 250 ml addition funnel, Y adapter, thermometer and Friedrich condenser is placed 208 grams of methional. The reaction mass is cooled to 0° C. and 100 ml of a 0.5 molar solution of sodium hydroxide is added dropwise with stirring. The resulting reaction mass is extracted with three 100 ml portions of methylene chloride and the extracts are combined, dried over anhydrous sodium sulfate and evaporated on a rotary evaporator. The resulting product was then subjected to vacuum distillation to give the product, boiling point 129° C. (1 mm Hg).

1. customInto a 1 liter reaction flask
2. customequipped with mechanical stirrer, 250 ml addition funnel
3. customThe resulting reaction mass
4. extractionis extracted with three 100 ml portions of methylene chloride
5. dry with materialdried over anhydrous sodium sulfate
6. customevaporated on a rotary evaporator
7. distillationThe resulting product was then subjected to vacuum distillation
8. customto give the product, boiling point 129° C. (1 mm Hg)