Isopropylamine → 2-Methyl-3-[4-(2-hydroxy-3-isopropylamino-propoxy)-phenyl]-7-methoxy-isoquinolin-1(2H)-one

HRID 262485Notes

Reaction equation

[CH3:1][N:2]1[C:11]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH:20]3[O:22][CH2:21]3)=[CH:14][CH:13]=2)=[CH:10][C:9]2[C:4](=[CH:5][C:6]([O:23][CH3:24])=[CH:7][CH:8]=2)[C:3]1=[O:25].[CH:26]([NH2:29])([CH3:28])[CH3:27]>>[CH3:1][N:2]1[C:11]([C:12]2[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH:20]([OH:22])[CH2:21][NH:29][CH:26]([CH3:28])[CH3:27])=[CH:16][CH:17]=2)=[CH:10][C:9]2[C:4](=[CH:5][C:6]([O:23][CH3:24])=[CH:7][CH:8]=2)[C:3]1=[O:25]

Participants

Reactant 2

HCID 6363Isopropylamine

HCID 213190402-methyl-3-[4-(2,3-epoxypropoxy)-phenyl]-7-methoxy-isoquinolin-1(2H)-one

Product 1

HCID 213190582-Methyl-3-[4-(2-hydroxy-3-isopropylamino-propoxy)-phenyl]-7-methoxy-isoquinolin-1(2H)-oneYield 63%

Procedure

2-Methyl-3-[4-(2-hydroxy-3-isopropylamino-propoxy)-phenyl]-7-methoxy-isoquinolin-1(2H)-one was prepared analogous to Example (1b) from 2-methyl-3-[4-(2,3-epoxypropoxy)-phenyl]-7-methoxy-isoquinolin-1(2H)-one and isopropylamine at a reaction temperature of 50° C.

Sources & evidence

ORD record: ord-9568c7d766c4425397854f524fa7e0f5
Source dataset: uspto-grants-1979_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04154837

Reaction notes

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