Isopropylamine → HCID 21319054, compound

HRID 262486Notes

Reaction equation

[CH3:1][N:2]1[C:11]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH:20]3[O:22][CH2:21]3)=[C:14]([O:23][CH3:24])[CH:13]=2)=[CH:10][C:9]2[C:4](=[CH:5][C:6]([O:25][CH3:26])=[CH:7][CH:8]=2)[C:3]1=[O:27].[CH:28]([NH2:31])([CH3:30])[CH3:29]>>[CH3:1][N:2]1[C:11]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH:20]([OH:22])[CH2:21][NH:31][CH:28]([CH3:30])[CH3:29])=[C:14]([O:23][CH3:24])[CH:13]=2)=[CH:10][C:9]2[C:4](=[CH:5][C:6]([O:25][CH3:26])=[CH:7][CH:8]=2)[C:3]1=[O:27]

Participants

Reactant 2

HCID 6363Isopropylamine

HCID 21319070HCID 21319070, compound

Product 1

HCID 21319054HCID 21319054, compoundYield 77%

Procedure

2-Methyl-3-[3-methoxy-4-(2-hydroxy-3-isopropylamino-propoxy)-phenyl]-7-methoxy-isoquinolin-1(2H)-one was prepared analogous to Example 1b from 2-methyl-3-[3-methoxy-4-(2,3-epoxypropoxy)-phenyl]-7-methoxy-isoquinolin-1(2H)-one and isopropylamine.

Sources & evidence

ORD record: ord-40d13feb276048c2b2b8049830adde5f
Source dataset: uspto-grants-1979_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04154837

Reaction notes

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