Benzenamine, N-ethyl-2-methoxy- → 7-Methoxyisoquinolin-1(2H)-one

HRID 262489Notes

Reaction equation

HRID 262489 reaction equation
C[N:2]1[C:11](CCC2C=CC(OCC3OC3)=C(OC)C=2)=[CH:10][C:9]2[C:4](=[CH:5][C:6]([O:27][CH3:28])=[CH:7][CH:8]=2)[C:3]1=[O:29].COC1C=CC=CC=1NCC>>[CH3:28][O:27][C:6]1[CH:5]=[C:4]2[C:9]([CH:10]=[CH:11][NH:2][C:3]2=[O:29])=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 10888090Benzenamine, N-ethyl-2-methoxy-HCID 21319052HCID 21319052, compound

Product 1

HCID 126435307-Methoxyisoquinolin-1(2H)-oneYield 74%

Procedure

2-Methyl-3-[3-methoxy-4-(3-(2-o-methoxy-phenyl-ethyl-amino)-2-hydroxy)-propoxy)-phenethyl]-7-methoxy-isoquinolin-1(2H)-one was prepared analogous to Example 2 from 2-methyl-3-[3-methoxy-4-(2,3-epoxypropoxy)-phenethyl]-7-methoxy-isoquinolin-1(2H)-one and 2-methoxyphenyl-ethylamine.

Sources & evidence

ORD record
ord-1949de563a9944399e1b98765cd3f0ba
Source dataset
uspto-grants-1979_05
Patent number
US04154837

Reaction notes

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