Water → HCID 14338588, compound

HRID 262497Notes

Reaction equation

HRID 262497 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]1[C:8](=[O:14])[NH:9][C:10](=[S:13])[NH:11][CH:12]=1.[CH3:15]I.[OH-].[Na+].O>C(O)C>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]1[C:8](=[O:14])[NH:9][C:10]([S:13][CH3:15])=[N:11][CH:12]=1

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 14338583HCID 14338583, compound

Product 1

HCID 14338588HCID 14338588, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-(2-Thienylmethyl)-2-thiouracil (4.5 g) was warmed at 65° with a mixture of methyl iodide (2.8 g), sodium hydroxide (0.8 g), water (75 ml) and ethanol (150 ml) to give 5-(2-thienylmethyl)-2-methylthio-4-pyrimidone (89%) m.p. 170.5°-171.5° (ethanol).

Sources & evidence

ORD record
ord-67da54281e3946c784f23b39f25ef988
Source dataset
uspto-grants-1979_05
Patent number
US04154834

Reaction notes

Loading…