Dimethylamine → (1R,2R)-N1,N1-Dimethylcyclohexane-1,2-diamine

A solution of the benzylamino compound was hydrogenated in two batches each containing 30.5 g. (0.131 mole), 175 ml. EtOH, 3.5 g Pd--C and 56.5 g. (0.394 mole) of 70% HClO4, at initial pressure of 51.5 p.s.i. for 19 hours. The two batches were combined, filtered through Celite and evaporated in vacuo at 45°. The residue was cooled in ice, basified with 40% KOH to pH 11. The resulting thick suspension was extracted with ether (5×200 ml), the ether extract was dried (MgSO4) and evaporated through a 9" Vigreux. The residue was distilled at 13 mm to give 32.5 g. (87% yield), b.p. 77°-78.5°. Vpc 100% at 3.8 mm. ir and nmr was identical to those of the sample prepared by the reaction of 7-azabicyclo[3.1.0]heptane with dimethylamine.

1. filtrationfiltered through Celite
2. customevaporated in vacuo at 45°
3. temperatureThe residue was cooled in ice
4. extractionThe resulting thick suspension was extracted with ether (5×200 ml)
5. extractionthe ether extract
6. dry with materialwas dried (MgSO4)
7. customevaporated through a 9" Vigreux
8. distillationThe residue was distilled at 13 mm
9. customto give 32.5 g

ORD record

ord-a27c606ae81d4bb39c0c1f12e43d608c

Source dataset

uspto-grants-1979_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04148914