Ethanol → Ethyl 2-thiazoleacrylate

HRID 262503Notes

Reaction equation

HRID 262503 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]=[CH:7][C:8]([OH:10])=[O:9].S(=O)(=O)(O)O.[CH2:16](O)[CH3:17]>>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]=[CH:7][C:8]([O:10][CH2:16][CH3:17])=[O:9]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 534018492-Thiazoleacrylic acid

Product 1

HCID 54075889Ethyl 2-thiazoleacrylate

Procedure

A solution of 2-thiazoleacrylic acid (26.76 g) and concentrated sulphuric acid (10 ml) in ethanol (150 ml) was refluxed for 18 hours. The solution was partially evaporated and dissolved in water. This solution was extracted with ether and the etheral extracts were evaporated to give ethyl 2-thiazoleacrylate.

Workup

  1. customThe solution was partially evaporated
  2. dissolutiondissolved in water
  3. extractionThis solution was extracted with ether
  4. customthe etheral extracts were evaporated

Sources & evidence

ORD record
ord-701e40adb0124f1f984272a6cd748fbc
Source dataset
uspto-grants-1979_05
Patent number
US04154834

Reaction notes

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