3-Pyridylmethyl-2-methylthio-4-pyrimidone → HCID 3055754, compound

HRID 262505Notes

Reaction equation

HRID 262505 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]2[C:9](=[O:16])[NH:10][C:11](SC)=[N:12][CH:13]=2)[CH:2]=1.[S:17]1[CH:21]=[CH:20][N:19]=[C:18]1[CH2:22][S:23][CH2:24][CH2:25][NH2:26]>>[S:17]1[CH:21]=[CH:20][N:19]=[C:18]1[CH2:22][S:23][CH2:24][CH2:25][NH:26][C:11]1[NH:10][C:9](=[O:16])[C:8]([CH2:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)=[CH:13][N:12]=1

Participants

3

Reactant 2

HCID 127838233-Pyridylmethyl-2-methylthio-4-pyrimidoneHCID 129234032-[(Thiazol-2-yl)methylthio]ethylamine

Product 1

HCID 3055754HCID 3055754, compound

Procedure

5-(3-Pyridylmethyl)-2-methylthio-4-pyrimidone (1.74 g) was reacted with 2-(2-thiazolylmethylthio)-ethylamine (1.30 g) according to the procedure in Example 2. The reaction mixture was triturated in hot water to give 2-[2-(2-thiazolylmethylthio)-ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone and this product was treated with dilute hydrobromic acid to give the title compound, m.p. 229°-233.5° (ex. methanol-water).

Workup

  1. customThe reaction mixture was triturated in hot water

Sources & evidence

ORD record
ord-29340ccd38d04ab88276b81ebd739183
Source dataset
uspto-grants-1979_05
Patent number
US04154834

Reaction notes

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