反应详情

5-(3-Pyridylmethyl)-2-methylthio-4-pyrimidone (1.74 g) was reacted with 2-(2-thiazolylmethylthio)-ethylamine (1.30 g) according to the procedure in Example 2. The reaction mixture was triturated in hot water to give 2-[2-(2-thiazolylmethylthio)-ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone and this product was treated with dilute hydrobromic acid to give the title compound, m.p. 229°-233.5° (ex. methanol-water).

1. customThe reaction mixture was triturated in hot water