Sulfuric Acid → Ethyl 3-quinolineacrylate

HRID 262509Notes

Reaction equation

HRID 262509 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([CH:11]=[CH:12][C:13]([OH:15])=[O:14])[CH:2]=1.S(=O)(=O)(O)O.Cl[C:22]1C(CSCCNC2NC(=S)C(CC3C=NC=CC=3)=CN=2)=NC=C[CH:27]=1.C(O)C.O>C(O)C>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([CH:11]=[CH:12][C:13]([O:15][CH2:22][CH3:27])=[O:14])[CH:2]=1

Participants

6

Reactant 4

HCID 1118Sulfuric AcidHCID 14722903-Quinolineacrylic acidHCID 19096565Water ethanolHCID 233491502-[2-(3-Chloro-2-pyridylmethylthio)ethylamino]-5-(3-pyridylmethyl)pyrimid-4-thione

Product 1

HCID 53657281Ethyl 3-quinolineacrylate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3-quinolineacrylic acid (63.71 g) and concentrated sulphuric acid (25 ml) in ethanol (350 ml) was refluxed for 18 hours. The product was obtained according to the procedure of Example 8 (i), giving ethyl 3-quinolineacrylate, m.p. 86.5°-88° (Ex ethanol-water).

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-c6a9438e5c814056a3193f6628e2bbb1
Source dataset
uspto-grants-1979_05
Patent number
US04154834

Reaction notes

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