反应详情

2-(3-Bromo-4-methyl-2-pyridylmethylthio)ethylamine (1.5 g) and 5-(3-pyridylmethyl)-2-methylthio-4-pyrimidone (1.0 g) were fused together at 160°-170° for 1 hour. The cool mixture was taken up in water at pH 2 and extracted with chloroform. The aqueous phase was adjusted to pH 7 and extracted with chloroform, and the chloroform extract was evaporated and the residue purified chromatographically on silica gel (eluting with chloroform/ammoniacal methanol 50:1) to give the title compound, m.p. 81°-85°

1. extractionextracted with chloroform
2. extractionextracted with chloroform
3. extractionthe chloroform extract
4. customwas evaporated
5. customthe residue purified chromatographically on silica gel (eluting with chloroform/ammoniacal methanol 50:1)