3-Pyridylmethyl-2-methylthio-4-pyrimidone → HCID 14338594, compound

HRID 262516Notes

Reaction equation

HRID 262516 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]2[C:9](=[O:16])[NH:10][C:11](SC)=[N:12][CH:13]=2)[CH:2]=1.[CH3:17][C:18]1[NH:22][CH:21]=[N:20][C:19]=1[CH2:23][S:24][CH2:25][CH2:26][CH2:27][NH2:28]>>[CH3:17][C:18]1[NH:22][CH:21]=[N:20][C:19]=1[CH2:23][S:24][CH2:25][CH2:26][CH2:27][NH:28][C:11]1[NH:10][C:9](=[O:16])[C:8]([CH2:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)=[CH:13][N:12]=1

Participants

3

Reactant 2

HCID 127838233-Pyridylmethyl-2-methylthio-4-pyrimidoneHCID 135205763-[(4-methyl-1H-imidazol-5-yl)methylthio]propylamine

Product 1

HCID 14338594HCID 14338594, compound

Procedure

An intimate mixture of 5-(3-pyridylmethyl)-2-methylthio-4-pyrimidone and 3-(5-methyl-4-imidazolylmethylthio)propylamine is heated at 130°-135° for 7 hours. The cool mixture is triturated with hot water and treated with dilute ethanolic HCl to give the trihydrochloride of the title compound.

Workup

  1. temperatureis heated at 130°-135° for 7 hours
  2. customThe cool mixture is triturated with hot water
  3. additiontreated with dilute ethanolic HCl

Sources & evidence

ORD record
ord-3a484ad070bc4c158be8cf2eb95a97e9
Source dataset
uspto-grants-1979_05
Patent number
US04154834

Reaction notes

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