HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl formate → Ethyl 2-(hydroxymethyl)-3-(3-pyridyl)butyrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl formate | HCID 8025 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Ethyl 3-(pyridin-3-yl)butanoate | HCID 12727116 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | Ethyl 2-(hydroxymethyl)-3-(3-pyridyl)butyrate | HCID 23349231 | — |
Reaction Steps
Treatment of ethyl 3-(3-pyridyl)butyrate with ethyl formate and sodium hydride in glyme, followed by acidification gave ethyl 2-(hydroxymethyl)-3-(3-pyridyl)butyrate, m.p. 128°-131°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04154834 |
| Source dataset | uspto-grants-1979_05 |
| ORD ID | ord-7ac13fcb344947da8d068eb15cffe5d7 |
| Source note | uspto-grants-1979_05 |