4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole → HCID 136136441, compound

HRID 262523Notes

Reaction equation

HRID 262523 reaction equation
CS[C:3]1[NH:8][C:7](=[O:9])[C:6]([CH2:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[C:5]([CH3:17])[N:4]=1.[CH3:18][C:19]1[NH:23][CH:22]=[N:21][C:20]=1[CH2:24][S:25][CH2:26][CH2:27][NH2:28]>N1C=CC=CC=1>[CH3:18][C:19]1[NH:23][CH:22]=[N:21][C:20]=1[CH2:24][S:25][CH2:26][CH2:27][NH:28][C:3]1[NH:8][C:7](=[O:9])[C:6]([CH2:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[C:5]([CH3:17])[N:4]=1

Participants

4

Reactant 2

HCID 6655684-(((2-Aminoethyl)thio)methyl)-5-methylimidazoleHCID 136045968HCID 136045968, compound

Product 1

HCID 136136441HCID 136136441, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Treatment of 2-methylthio-5-(3-pyridylmethyl)-6-methyl-4-pyrimidone with 2-(5-methyl-4-imidazolylmethylthio)ethylamine in refluxing pyridine for 25 hours, followed by evaporation of the mixture and chromatographic purification of the residue on silica gel (eluting with chloroform/methanol 5:1) gave 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-pyridylmethyl)-6-methyl-4-pyrimidone m.p. 128°-131°.

Workup

  1. customfollowed by evaporation of the mixture and chromatographic purification of the residue on silica gel (eluting with chloroform/methanol 5:1)

Sources & evidence

ORD record
ord-1f022d0d3cd444e2829b22f18e359ae0
Source dataset
uspto-grants-1979_05
Patent number
US04154834

Reaction notes

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