Sodium Hydroxide → HCID 21319288, compound

Participants

Reaction Steps

A solution of sodium dithionite (2.05 g, 11.8 mmol) dissolved in 20 ml water and 5 ml concentrated ammonium hydroxide is added to the ethyl 3-nitro-4-aminobenzyl sulfide (1 g, 3.9 mmol) stirred in 20 ml 95% ethanol. The mixture is heated to reflux and 0.6 g sodium dithionite in 2 ml water and 0.5 ml ammonium hydroxide is added immediately. The mixture becomes colorless, is cooled to room temperature, basified with 5 ml 10% sodium hydroxide, evaporated to 1/2 volume, and washed with chloroform (X 5). The combined chloroform washings are washed with brine, dried (Na2SO4), and evaporated to give 0.65 g (92%) of an oil which is used without further purification.

Provenance & Evidence