Hydrochloric Acid → HCID 53946840, compound

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Reaction Steps

A mixture of 26 ml of fuming hydrochloric acid, 3.9 g of stannous chloride dihydrate and 1.3 g of 2-nitro-7-methylamino-6,7-dihydro [5H] benzocycloheptene hydrochloride was stirred at room temperature for 16 hours and was then cooled to 10° C. for the addition of 100 ml of water. The mixture was made alkaline at 10° C. with concentrated ammonium hydroxide and was then extracted 3 times with 50 ml of methylene chloride. The organic extracts were washed with water, dried over sodium sulfate and evaporated to dryness under reduced pressure to obtain 1 g of 2-amino-7-methylamino-6,7-dihydro [5H] benzocycloheptene in the form of a brown oil.

Provenance & Evidence