反应详情

295g of cyclohexanone and 261 g of morpholine are dissolved in 800ml of benzene. After the whole has been dissolved, 1.5g of p. toluene sulphonic acid are added and the mixture is heated under reflux. The water formed is extracted continuously by azeotropic distillation. After 20 hours reflux, the remaining solvent is distilled off and the oily residue is recovered. 379 g of the enamine are so obtained, boiling under 2mm at 115° to 117°. The yield amounts to 76%.

1. dissolutionAfter the whole has been dissolved
2. temperaturethe mixture is heated
3. temperatureunder reflux
4. extractionis extracted continuously by azeotropic distillation
5. temperatureAfter 20 hours reflux
6. distillationthe remaining solvent is distilled off
7. customthe oily residue is recovered