Sodium Hydroxide → HCID 12859680, compound

HRID 262542Notes

Reaction equation

HRID 262542 reaction equation
[CH3:1][CH:2]([CH3:14])[CH2:3][CH2:4][C:5]([CH:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C:8]1=[O:13])=[O:6].[OH-:15].[Na+]>>[O:6]=[C:5]([CH2:4][CH2:3][CH:2]([CH3:1])[CH3:14])[CH2:7][CH2:12][CH2:11][CH2:10][CH2:9][C:8]([OH:13])=[O:15]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 128596792-(4-Methyl-1-oxopentyl)cyclohexanone

Product 1

HCID 12859680HCID 12859680, compound

Procedure

10 g of 2-(4'-methyl valeryl) cyclohexanone are added to 70ml of a 5% aqueous solution of sodium hydroxide. The mixture is heated under reflux for 2 hours. The aqueous solution is then made acidic with a 4 N solution of hydrochloric acid and is extracted with ether. The ethereous phase is separated, is washed with a saturated solution of sodium chloride, is dried on sodium sulphate, is filtered and is evaporated to dryness. The solid residue weighing 9g is left to stand at room temperature. The crystallization begins quickly. The crystals are recovered and are recrystallized from n- pentane (yield 6.2g).

Workup

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 2 hours
  3. extractionmade acidic with a 4 N solution of hydrochloric acid and is extracted with ether
  4. customThe ethereous phase is separated
  5. washis washed with a saturated solution of sodium chloride
  6. customis dried on sodium sulphate
  7. filtrationis filtered
  8. customis evaporated to dryness
  9. waitis left
  10. customto stand at room temperature
  11. customThe crystallization
  12. customThe crystals are recovered
  13. customare recrystallized from n- pentane (yield 6.2g)

Sources & evidence

ORD record
ord-9a94a5e4c5a64d8bab00e47fbb8bc49e
Source dataset
uspto-grants-1979_05
Patent number
US04154851

Reaction notes

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