1-(3-Mercapto-1-oxopropyl)-L-proline → 1-[3-[[(ethylamino)carbonyl]thio]-2-benzylpropanoyl]-L-proline

HRID 262567Notes

Reaction equation

HRID 262567 reaction equation
[SH:1][CH2:2][CH:3]([CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:4]([N:6]1[CH2:13][CH2:12][CH2:11][C@H:7]1[C:8]([OH:10])=[O:9])=[O:5].SCC[C:24]([N:26]1CCC[C@H:27]1[C:28](O)=O)=[O:25]>>[CH2:27]([NH:26][C:24]([S:1][CH2:2][CH:3]([CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:4]([N:6]1[CH2:13][CH2:12][CH2:11][C@H:7]1[C:8]([OH:10])=[O:9])=[O:5])=[O:25])[CH3:28]

Participants

3

Reactant 2

HCID 999781-(3-Mercapto-1-oxopropyl)-L-prolineHCID 183972851-[3-Phenyl-2-(sulfanylmethyl)propanoyl]-L-proline

Product 1

HCID 541082071-[3-[[(ethylamino)carbonyl]thio]-2-benzylpropanoyl]-L-proline

Procedure

By substituting 1-(3-mercapto-2-benzylpropanoyl)-L-proline for the 1-(3-mercaptopropanoyl)-L-proline in the procedure of Example 65, 1-[3-[[(ethylamino)carbonyl]thio]-2-benzylpropanoyl]-L-proline is obtained.

Sources & evidence

ORD record
ord-75ea4dfbc7194853a1e5c47e7c196474
Source dataset
uspto-grants-1979_05
Patent number
US04154840

Reaction notes

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