HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron trifluoride etherate → 3-(Tetrahydropyran-2-ylthio)-2-methylpropanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron trifluoride etherate | HCID 8000 | — |
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Mercaptoisobutyric acid | HCID 152910 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 3-(Tetrahydropyran-2-ylthio)-2-methylpropanoic acid | HCID 21319138 | — |
Reaction Steps
To a solution of 3-mercapto-2-methylpropanoic acid (2.4 g.) and freshly distilled 2,3-dihydro-4H-pyrane (1.9 g.) in benzene (60 ml.), boron trifluoride etherate (2.8 g.) is added. After two hours, potassium carbonate (4 g.) is added, the mixture is stirred and filtered. The filtrate is concentrated to dryness to yield 3-(tetrahydropyran-2-ylthio)-2-methylpropanoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04154840 |
| Source dataset | uspto-grants-1979_05 |
| ORD ID | ord-10307668966946388033a050c144c49e |
| Source note | uspto-grants-1979_05 |