HCID 13208321, compound → 1-(2-Methyl-3-sulfanylpropanoyl)-L-proline

HRID 262585Notes

Reaction equation

HRID 262585 reaction equation
C([O:5][C:6](=[O:18])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:17])[CH:13]([CH3:16])[CH2:14][SH:15])(C)(C)C.C(OC(=O)[C@@H]1CCCN1C(=O)CCS)(C)(C)C>>[SH:15][CH2:14][CH:13]([CH3:16])[C:12]([N:8]1[CH2:9][CH2:10][CH2:11][C@H:7]1[C:6]([OH:18])=[O:5])=[O:17]

Participants

3

Reactant 2

HCID 13208321HCID 13208321, compoundHCID 54491354HCID 54491354, compound

Product 1

HCID 128775471-(2-Methyl-3-sulfanylpropanoyl)-L-proline

Procedure

By substituting 1-(3-mercapto-2-methylpropanoyl)-L-proline tert.butyl ester for the 1-(3-mercaptopropanoyl-L-proline tert.butyl ester in the procedure of Example 18C, 1-(3-mercapto-2-methylpropanoyl)-L-proline is obtained. Rf 0.35 (Silica gel, Benzene/acetic acid 3:1), Rf 0.5 (Silica gel, Methyl-ethylketone/Acetic acid/Pyridine/Water 14:1:2:1), identical to the compound of Example 34.

Sources & evidence

ORD record
ord-58b77214e68c4be5a5be7e91d72b2640
Source dataset
uspto-grants-1979_05
Patent number
US04154840

Reaction notes

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