3-[(2-Aminoethyl)thiomethyl]pyridazine → N-nitro-N'-[2-(3-pyridazinylmethylthio)ethyl)guanidine

HRID 262625Notes

Reaction equation

HRID 262625 reaction equation
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[N:7]=[N:8][CH:9]=[CH:10][CH:11]=1.CS[C:14](=[NH:19])[NH:15][N+:16]([O-:18])=[O:17]>>[N+:16]([NH:15][C:14]([NH:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[N:7]=[N:8][CH:9]=[CH:10][CH:11]=1)=[NH:19])([O-:18])=[O:17]

Participants

3

Reactant 2

HCID 202425053-[(2-Aminoethyl)thiomethyl]pyridazineHCID 135927615N-Nitro-S-methylisothiourea

Product 1

HCID 178512217N-nitro-N'-[2-(3-pyridazinylmethylthio)ethyl)guanidine

Procedure

Reaction of 3-[(2-aminoethyl)thiomethyl]-pyridazine with S-methyl-N-nitroisothiourea by the procedure of Example 2(ii) gives N-nitro-N'-[2-(3-pyridazinylmethylthio)ethyl]guanidine. Similarly, by the procedure of Example 2(iii), there is obtained N-methyl-N'-nitro-N"-[2-(3-pyridazinylmethylthio)ethyl]-guanidine.

Sources & evidence

ORD record
ord-4831b1d8b3fc4edaa7c8d2dde797036e
Source dataset
uspto-grants-1979_05
Patent number
US04154844

Reaction notes

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