HCID 54200145, compound → HCID 54282494, compound

HRID 262711Notes

Reaction equation

HRID 262711 reaction equation
C([S:4][CH:5]([C:16]([F:19])([F:18])[F:17])[C:6]([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10]([OH:12])=[O:11])=[O:7])(=O)C>O.N>[SH:4][CH:5]([C:16]([F:19])([F:17])[F:18])[C:6]([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10]([OH:12])=[O:11])=[O:7]

Participants

4

Reactant 1

HCID 54200145HCID 54200145, compound

Product 1

HCID 54282494HCID 54282494, compound

Reagents, catalysts & solvents 2

HCID 222AmmoniaSolventHCID 962WaterSolvent

Procedure

1-(2-Acetylthio-3,3,3-trifluoropropanoyl)-L-proline (4 g.) is dissolved in a mixture of water (8 ml.) and concentrated ammonia (8 ml.) under a blanket of nitrogen. After thirty minutes at room temperature, the reaction mixture is acidified and extracted with ethyl acetate. The organic phase is dried over magnesium sulfate and concentrated to dryness in vacuo to yield 1-(2-mercapto-3,3,3-trifluoropropanoyl)-L-proline.

Workup

  1. waitAfter thirty minutes at room temperature
  2. extractionextracted with ethyl acetate
  3. dry with materialThe organic phase is dried over magnesium sulfate
  4. concentrationconcentrated to dryness in vacuo

Sources & evidence

ORD record
ord-eeab31b27fc7482c8aa7b27217b12c85
Source dataset
uspto-grants-1979_05
Patent number
US04154935

Reaction notes

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