(Pyrazin-2-yl)methanamine → HCID 178506607, compound

HRID 262769Notes

Reaction equation

HRID 262769 reaction equation
[IH:1].[C:2](=[NH:7])(SC)[NH:3][NH2:4].[NH2:8][CH2:9][C:10]1[CH:15]=[N:14][CH:13]=[CH:12][N:11]=1>C(O)C>[IH:1].[NH2:4][NH:3][C:2]([NH:8][CH2:9][C:10]1[CH:15]=[N:14][CH:13]=[CH:12][N:11]=1)=[NH:7]

Participants

4

Reactant 2

HCID 266781(Pyrazin-2-yl)methanamineHCID 178504064HCID 178504064, compound

Product 1

HCID 178506607HCID 178506607, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3.66 g. of methyl thiocarbazimidate hydriodide and 3.42 g. of (aminomethyl)pyrazine [A. Hirschberg and P. Mattner, J. Med. Chem., 11, 911 (1961)] in 50 ml. of absolute ethanol is heated at reflux for 20 hours and then concentrated to dryness under reduced pressure to give the desired product as an orange solid.

Workup

  1. temperatureat reflux for 20 hours
  2. concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-e07fb3ba6e99488eb4cea33d787f021e
Source dataset
uspto-grants-1979_05
Patent number
US04154947

Reaction notes

Loading…