HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 1-(4-Chlorophenyl)-1H-pyrazol-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 1-(4-Chlorophenyl)-4,5-dihydro-1H-pyrazol-3-amine | HCID 12551450 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(4-Chlorophenyl)-1H-pyrazol-3-amine | HCID 13626945 | 51.6% |
Reaction Steps
In the same apparatus and according to the same modalities as in Example 1, 1.95 g (0.01 mole) of 1-(p-chlorophenyl)-3-amino-2-pyrazoline were suspended in 12 ml of ethanol and 0.1 ml of pyridine with addition of 0.1 g of CuCl, under an oxygen head. Oxidation was completed after about 10 hours. The oxidized product was isolated as in Example 2, thus obtaining 1 g of 1-(p-chlorophenyl)-3-amino-pyrazole of melting point 107°-108° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04149005 |
| Source dataset | uspto-grants-1979_04 |
| ORD ID | ord-3ac92cd603c94cc285cb3485c7edd28e |
| Source note | uspto-grants-1979_04 |