反应详情

A solution of 2.83 g. of 2,6-dichlorobenzaldehyde and 1-amino-3-(pyrazinylmethyl)guanidine hydriodide from Example 10 in 50 ml. of absolute ethanol and 5.0 ml. of glacial acetic acid is heated at reflux for 4 hours. The cooled solution is made basic by addition of 10N sodium hydroxide and extracted with ether. The ether extract is evaporated to give a residual orange gum which is crystallized from absolute ethanol to give the desired product as colorless crystals, m.p. 168°-169° C.

1. temperatureat reflux for 4 hours
2. extractionextracted with ether
3. extractionThe ether extract
4. customis evaporated
5. customto give a residual orange gum which
6. customis crystallized from absolute ethanol