反应详情

To a solution of 2,2-dimethyl-7-dimethylaminoethyloxy-4-(3-trifluoromethylphenyl)-2H-chromene hydrochloride (4.96 g) in ethanol (75 ml) was added 10% palladium on charcoal. The mixture was hydrogenated under hydrogen (1 atmosphere pressure) at ambient temperature (about 18° C.) until no further hydrogen was taken up. The mixture was filtered and the solvent removed from the resulting filtrate under reduced pressure to yield the title compound (3.7 g), m.p. 188°-190° C.

1. customwas hydrogenated under hydrogen (1 atmosphere pressure) at ambient temperature
2. custom(about 18° C.)
3. filtrationThe mixture was filtered
4. customthe solvent removed from the resulting filtrate under reduced pressure