1-(3-acetylthio-2-aminomethylpropanoyl)-L-proline → 1-(2-aminomethyl-3-mercaptopropanoyl)-L-proline

HRID 262802Notes

Reaction equation

HRID 262802 reaction equation
C([S:4][CH2:5][CH:6]([CH2:17][NH2:18])[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])(=O)C.FC(F)(F)C(O)=O.C(SCC(CCCN)C(N1CCC[C@H]1C(O)=O)=O)(=O)C>>[NH2:18][CH2:17][CH:6]([CH2:5][SH:4])[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8]

Participants

3

Reactant 2

HCID 537828151-(3-acetylthio-2-aminomethylpropanoyl)-L-prolineHCID 867360071-(2-acetylthiomethyl-5-aminopentanoyl)-L-proline trifluoroacetate

Product 1

HCID 228053391-(2-aminomethyl-3-mercaptopropanoyl)-L-proline

Procedure

By substituting 1-(3-acetylthio-2-aminomethylpropanoyl)-L-proline for the 1-(2-acetylthiomethyl-5-aminopentanoyl)-L-proline trifluoroacetate in the procedure of Example 15, 1-(2-aminomethyl-3-mercaptopropanoyl)-L-proline is obtained.

Sources & evidence

ORD record
ord-f4304a54d5cc45aaac7abbc209691920
Source dataset
uspto-grants-1979_05
Patent number
US04154946

Reaction notes

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